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Article

SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.

Cell - 5 Nov 1993

Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser S M

Abstract excerpt

Heritable inactivation of genes occurs in specific chromosomal domains located at the silent mating type loci and at telomeres of S. cerevisiae. The SIR genes (for silent information regulators) are trans-acting factors required for this repression mechanism. We show here that the SIR3 and SIR4 gene products have a sub-nuclear localization similar to the telomere-associated RAP1 protein, which is found primarily...

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Source

Identifiers

PMID: 8221893
DOI: 10.1016/0092-8674(93)90388-7

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.PMID 8221893Read ↗

The clustering of telomeres and colocalization with Rap1, Sir3, and Sir4 proteins in wild-type Saccharomyces cerevisiae.Semantic proximity Read ↗

Two classes of sir3 mutants enhance the sir1 mutant mating defect and abolish telomeric silencing in Saccharomyces cerevisiae.Semantic proximity Read ↗

The positioning of yeast telomeres depends on SIR3, SIR4, and the integrity of the nuclear membrane.Semantic proximity Read ↗

C-terminal truncation of RAP1 results in the deregulation of telomere size, stability, and function in Saccharomyces cerevisiae.Semantic proximity Read ↗

Nuclear organization and transcriptional silencing in yeast.Semantic proximity Read ↗

Yeast Rap1 contributes to genomic integrity by activating DNA damage repair genes.Semantic proximity Read ↗

Hyperactivation of the silencing proteins, Sir2p and Sir3p, causes chromosome loss.Semantic proximity Read ↗

Activation of an MAP kinase cascade leads to Sir3p hyperphosphorylation and strengthens transcriptional silencing.Semantic proximity Read ↗

Spreading of transcriptional repressor SIR3 from telomeric heterochromatin.Semantic proximity Read ↗

Structural and functional studies of the Rap1 C-terminus reveal novel separation-of-function mutants.Semantic proximity Read ↗

A genetic screen for ribosomal DNA silencing defects identifies multiple DNA replication and chromatin-modulating factors.Semantic proximity Read ↗

Sif2p interacts with Sir4p amino-terminal domain and antagonizes telomeric silencing in yeast.Semantic proximity Read ↗

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