Article
SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres.
Cell - 5 Nov 1993
Palladino F, Laroche T, Gilson E, Axelrod A, Pillus L, Gasser S M
Abstract excerpt
Heritable inactivation of genes occurs in specific chromosomal domains located at the silent mating type loci and at telomeres of S. cerevisiae. The SIR genes (for silent information regulators) are trans-acting factors required for this repression mechanism. We show here that the SIR3 and SIR4 gene products have a sub-nuclear localization similar to the telomere-associated RAP1 protein, which is found primarily...
Topics
- Cell Compartmentation
- Cell Nucleus
- Fluorescent Antibody Technique
- Fungal Proteins
- GTP-Binding Proteins
- Gene Expression Regulation, Fungal
- Mating Factor
- Mitosis
- Mutagenesis
- Mutation
- Peptides