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Article

Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury.

Circulation research - 28 Oct 2005

Imahashi Kenichi, Pott Christian, Goldhaber Joshua I, Steenbergen Charles, Philipson Kenneth D, Murphy Elizabeth

Abstract excerpt

During ischemia and reperfusion, with an increase in intracellular Na+ and a depolarized membrane potential, Ca2+ may enter the myocyte in exchange for intracellular Na+ via reverse-mode Na+-Ca2+ exchange (NCX). To test the role of Ca2+ entry via NCX during ischemia and reperfusion, we studied mice with cardiac-specific ablation of NCX (NCX-KO) and demonstrated that reverse-mode Ca2+ influx is absent in the...

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Source

Identifiers

PMID: 16179590
DOI: 10.1161/01.RES.0000187456.06162.cb

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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