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Article

Cardiac function is regulated by the sodium-dependent inhibition of the sodium-calcium exchanger NCX1.

Nature communications - 7 May 2024

Scranton Kyle, John Scott, Angelini Marina, Steccanella Federica, Umar Soban, Zhang Rui, Goldhaber Joshua I, Olcese Riccardo, Ottolia Michela

Abstract excerpt

The Na+-Ca2+ exchanger (NCX1) is the dominant Ca2+ extrusion mechanism in cardiac myocytes. NCX1 activity is inhibited by intracellular Na+ via a process known as Na+-dependent inactivation. A central question is whether this inactivation plays a physiological role in heart function. Using CRISPR/Cas9, we inserted the K229Q mutation in the gene (Slc8a1) encoding for NCX1. This mutation removes the Na+-dependent...

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Identifiers

PMID: 38714663
DOI: 10.1038/s41467-024-47850-z
PMCID: PMC11076594

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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