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Mitochondrial CaMKII causes adverse metabolic reprogramming and dilated cardiomyopathy

4 Sept 2020

Abstract excerpt

Abstract Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. Here, we report increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventricular dilation in mice one week after myocardial infarction (MI) surgery. By contrast,...

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PMID: 32887881
DOI: 10.1038/s41467-020-18165-6

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