Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.

doi:10.1161/CIRCHEARTFAILURE.116.003523

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.

Circulation. Heart failure - 1 Feb 2017

Zhang Bo, Novitskaya Tatiana, Wheeler Debra G, Xu Zhaobin, Chepurko Elena, Huttinger Ryan, He Heng, Varadharaj Saradhadevi, Zweier Jay L, Song Yanna, Xu Meng, Harrell Frank E, Su Yan Ru, Absi Tarek, Kohr Mark J, Ziolo Mark T, Roden Dan M, Shaffer Christian M, Galindo Cristi L, Wells Quinn S, Gumina Richard J

Abstract excerpt

BACKGROUND: Despite increased secondary cardiovascular events in patients with ischemic cardiomyopathy (ICM), the expression of innate cardiac protective molecules in the hearts of patients with ICM is incompletely characterized. Therefore, we used a nonbiased RNAseq approach to determine whether differences in cardiac protective molecules occur with ICM. METHODS AND RESULTS: RNAseq analysis of human control and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calcium Channels, L-Type

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Myocardial Reperfusion Injury

Share to Potassium Channels, Inwardly Rectifying

Share to Reactive Nitrogen Species

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Share to Ventricular Dysfunction, Left

Share to Ventricular Function, Left

Source

Open in PubMed Open full text

Identifiers

PMID: 28209764
DOI: 10.1161/CIRCHEARTFAILURE.116.003523
PMCID: PMC5319711

Genes

KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kcnj11 Ablation Is Associated With Increased Nitro-Oxidative Stress During Ischemia-Reperfusion Injury: Implications for Human Ischemic Cardiomyopathy.PMID 28209764Read ↗

Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury.Semantic proximity Read ↗

Deletion of the ion channel <i>Trpm4</i> increases cardiac inflammatory markers and fibrosis after myocardial infarction in miceSemantic proximity Read ↗

Protein Aggregation Is an Early Manifestation of Phospholamban p.(Arg14del)-Related Cardiomyopathy: Development of PLN-R14del-Related Cardiomyopathy.Semantic proximity Read ↗

NETosis and Myeloperoxidase Promotes Inflammation and Cardiac Remodeling in Arrhythmogenic CardiomyopathySemantic proximity Read ↗

Cardioprotection via preserved mitochondrial structure and function in the mPer2-mutant mouse myocardium.Semantic proximity Read ↗

Targeting DNA methylation can reduce cardiac injury associated with ischemia reperfusion: One step closer to clinical translation with blood-borne assessmentSemantic proximity Read ↗

Mitochondrial calcium overload is a key determinant in heart failure.Semantic proximity Read ↗

The phospholamban p.(Arg14del) pathogenic variant leads to cardiomyopathy with heart failure and is unreponsive to standard heart failure therapy.Semantic proximity Read ↗

S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy.Semantic proximity Read ↗

The denitrosylase SCoR2 controls cardioprotective metabolic reprogrammingSemantic proximity Read ↗

Exercise-Induced Epoxy-Eicosanoids Promote Cardiomyocyte Proliferation and Post-Infarction Repair via NR4A1Semantic proximity Read ↗

CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.