Article
CaMKII-dependent phosphorylation of cardiac ryanodine receptors regulates cell death in cardiac ischemia/reperfusion injury.
Journal of molecular and cellular cardiology - 1 Sept 2014
Di Carlo Mariano N, Said Matilde, Ling Haiyun, Valverde Carlos A, De Giusti Verónica C, Sommese Leandro, Palomeque Julieta, Aiello Ernesto A, Skapura Darlene G, Rinaldi Gustavo, Respress Jonathan L, Brown Joan Heller, Wehrens Xander H T, Salas Margarita A, Mattiazzi Alicia
Abstract excerpt
Ca(2+)-calmodulin kinase II (CaMKII) activation is deleterious in cardiac ischemia/reperfusion (I/R). Moreover, inhibition of CaMKII-dependent phosphorylations at the sarcoplasmic reticulum (SR) prevents CaMKII-induced I/R damage. However, the downstream targets of CaMKII at the SR level, responsible for this detrimental effect, remain unclear. In the present study we aimed to dissect the role of the two main...
Topics
Join the communities discussing this publication.