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Article

AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.

PloS one - 1 Jan 2012

Park Chang Sik, Cha Hyeseon, Kwon Eun Jeong, Jeong Dongtak, Hajjar Roger J, Kranias Evangelia G, Cho Chunghee, Park Woo Jin, Kim Do Han

Abstract excerpt

BACKGROUND: Histidine-rich calcium binding protein (HRC) is located in the lumen of sarcoplasmic reticulum (SR) that binds to both triadin (TRN) and SERCA affecting Ca(2+) cycling in the SR. Chronic overexpression of HRC that may disrupt intracellular Ca(2+) homeostasis is implicated in pathogenesis of cardiac hypertrophy. Ablation of HRC showed relatively normal phenotypes under basal condition, but exhibited a...

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Source

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Identifiers

PMID: 22952658
DOI: 10.1371/journal.pone.0043282
PMCID: PMC3429470

Genes

HRC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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AAV-mediated knock-down of HRC exacerbates transverse aorta constriction-induced heart failure.PMID 22952658Read ↗

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