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Article

Induced overexpression of phospholemman S68E mutant improves cardiac contractility and mortality after ischemia-reperfusion.

American journal of physiology. Heart and circulatory physiology - 1 Apr 2014

Wang JuFang, Song Jianliang, Gao Erhe, Zhang Xue-Qian, Gu Tongda, Yu Daohai, Koch Walter J, Feldman Arthur M, Cheung Joseph Y

Abstract excerpt

Phospholemman (PLM), when phosphorylated at Ser(68), inhibits cardiac Na+ / Ca2+ exchanger 1 (NCX1) and relieves its inhibition on Na+ -K+ -ATPase. We have engineered mice in which expression of the phosphomimetic PLM S68E mutant was induced when dietary doxycycline was removed at 5 wk. At 8-10 wk, compared with noninduced or wild-type hearts, S68E expression in induced hearts was ∼35-75% that of endogenous PLM,...

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Identifiers

PMID: 24486513
DOI: 10.1152/ajpheart.00861.2013
PMCID: PMC3962630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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