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Article

RhoA protects the mouse heart against ischemia/reperfusion injury.

The Journal of clinical investigation - 1 Aug 2011

Xiang Sunny Yang, Vanhoutte Davy, Del Re Dominic P, Purcell Nicole H, Ling Haiyun, Banerjee Indroneal, Bossuyt Julie, Lang Richard A, Zheng Yi, Matkovich Scot J, Miyamoto Shigeki, Molkentin Jeffery D, Dorn Gerald W, Brown Joan Heller

Abstract excerpt

The small GTPase RhoA serves as a nodal point for signaling through hormones and mechanical stretch. However, the role of RhoA signaling in cardiac pathophysiology is poorly understood. To address this issue, we generated mice with cardiomyocyte-specific conditional expression of low levels of activated RhoA (CA-RhoA mice) and demonstrated that they exhibited no overt cardiomyopathy. When challenged by in vivo or...

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Identifiers

PMID: 21747165
DOI: 10.1172/JCI44371
PMCID: PMC3148727

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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