Article

Mitochondrial CaMKII causes metabolic reprogramming, energetic insufficiency, and dilated cardiomyopathy

2020-02-14

Abstract excerpt

Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. We found increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventricular dilation in mice one week after myocardial infarction (MI) surgery. In contrast, mice with genetic...

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Literature Corpus work: f361ff3f-dfff-58a9-a2e2-f83d2e4ded46
DOI: 10.1101/2020.02.13.947564

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