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Article

Regulation of cardiac myocyte contractility by phospholemman: Na+/Ca2+ exchange versus Na+ -K+ -ATPase.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2008

Song Jianliang, Zhang Xue-Qian, Wang JuFang, Cheskis Ellina, Chan Tung O, Feldman Arthur M, Tucker Amy L, Cheung Joseph Y

Abstract excerpt

Phospholemman (PLM) regulates cardiac Na(+)/Ca(2+) exchanger (NCX1) and Na(+)-K(+)-ATPase in cardiac myocytes. PLM, when phosphorylated at Ser(68), disinhibits Na(+)-K(+)-ATPase but inhibits NCX1. PLM regulates cardiac contractility by modulating Na(+)-K(+)-ATPase and/or NCX1. In this study, we f...

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Identifiers

PMID: 18708446
DOI: 10.1152/ajpheart.00287.2008
PMCID: PMC2593504

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18708446-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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