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Article

CD4 and MHC class 1 down-modulation activities of nef alleles from brain- and lymphoid tissue-derived primary HIV-1 isolates.

Journal of neurovirology - 1 Feb 2011

Gray Lachlan R, Gabuzda Dana, Cowley Daniel, Ellett Anne, Chiavaroli Lisa, Wesselingh Steven L, Churchill Melissa J, Gorry Paul R

Abstract excerpt

Human immunodeficiency virus type 1 (HIV-1) nef undergoes adaptive evolution in the central nervous system (CNS), reflecting altered requirements for HIV-1 replication in macrophages/microglia and brain-specific immune selection pressures. The role of Nef in HIV-1 neurotropism and pathogenesis of HIV-associated dementia (HAD) is unclear. In this study, we characterized 82 nef alleles cloned from brain, cerebral...

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Source

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Identifiers

PMID: 21165790
DOI: 10.1007/s13365-010-0001-6
PMCID: PMC4395859

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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