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Article

CTL escape mediated by proteasomal destruction of an HIV-1 cryptic epitope.

PLoS pathogens - 1 May 2011

Cardinaud Sylvain, Consiglieri Gesa, Bouziat Romain, Urrutia Alejandra, Graff-Dubois Stéphanie, Fourati Slim, Malet Isabelle, Guergnon Julien, Guihot Amélie, Katlama Christine, Autran Brigitte, van Endert Peter, Lemonnier François A, Appay Victor, Schwartz Olivier, Kloetzel Peter M, Moris Arnaud

Abstract excerpt

Cytotoxic CD8+ T cells (CTLs) play a critical role in controlling viral infections. HIV-infected individuals develop CTL responses against epitopes derived from viral proteins, but also against cryptic epitopes encoded by viral alternative reading frames (ARF). We studied here the mechanisms of HIV-1 escape from CTLs targeting one such cryptic epitope, Q9VF, encoded by an HIVgag ARF and presented by HLA-B*07....

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Share to gag Gene Products, Human Immunodeficiency Virus
Share to Antigen Presentation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epitopes, T-Lymphocyte

Share to HIV Antigens

Share to HLA-B7 Antigen

Share to Proteasome Endopeptidase Complex

Share to T-Lymphocytes, Cytotoxic

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Source

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Identifiers

PMID: 21589903
DOI: 10.1371/journal.ppat.1002049
PMCID: PMC3093368

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