Article
Aminopeptidase substrate preference affects HIV epitope presentation and predicts immune escape patterns in HIV-infected individuals.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2012
Zhang Shao Chong, Martin Eric, Shimada Mariko, Godfrey Sasha Blue, Fricke Jennifer, Locastro Shirley, Lai Nicole Y, Liebesny Paul, Carlson Jonathan M, Brumme Chanson J, Ogbechie Oluwatobi Awele, Chen Huabiao, Walker Bruce D, Brumme Zabrina L, Kavanagh Daniel G, Le Gall Sylvie
Abstract excerpt
Viruses evade immune detection partly through immune-associated mutations. Analyses of HIV sequences derived from infected individuals have identified numerous examples of HLA-associated mutations within or adjacent to T cell epitopes, but the potential impact of most mutations on epitope production and presentation remains unclear. The multistep breakdown of proteins into epitopes includes trimming of N-extended...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.