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Article

The role of BRCA1 in non-homologous end-joining.

Cancer letters - 18 Aug 2006

Bau Da-Tian, Mau Yi-Chien, Shen Chen-Yang

Abstract excerpt

From the genotypic viewpoint, single nucleotide polymorphisms in the genes of the non-homologous end-joining (NHEJ) pathway, which is important in the repair of DNA double-strand breaks, have been shown to be associated with increased breast cancer risk. However, more phenotypic evidence is needed to strengthen the link between defective NHEJ genes and breast cancer development. Recently, BRCA1-deficient mouse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16171943
DOI: 10.1016/j.canlet.2005.08.003

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The role of BRCA1 in non-homologous end-joining.PMID 16171943Read ↗

Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.Semantic proximity Read ↗

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A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.Semantic proximity Read ↗

Clinical variability and novel mutations in the NHEJ1 gene in patients with a Nijmegen breakage syndrome-like phenotype.Semantic proximity Read ↗

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.Semantic proximity Read ↗

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