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Article

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.

The Biochemical journal - 1 Feb 2012

Dohrn Lisa, Salles Daniela, Siehler Simone Y, Kaufmann Julia, Wiesmüller Lisa

Abstract excerpt

BACH1 (BRCA1-associated C-terminal helicase 1), the product of the BRIP1 {BRCA1 [breast cancer 1, early onset]-interacting protein C-terminal helicase 1; also known as FANCJ [FA-J (Fanconi anaemia group J) protein]} gene mutated in Fanconi anaemia patients from complementation group J, has been implicated in DNA repair and damage signalling. BACH1 exerts DNA helicase activities and physically interacts with BRCA1...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22032289
DOI: 10.1042/BJ20110314

Genes

BACH1
BRCA1
MLH1
BRIP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

BRCA1-mediated repression of mutagenic end-joining of DNA double-strand breaks requires complex formation with BACH1.PMID 22032289Read ↗

Assessing the link between BACH1/FANCJ and MLH1 in DNA crosslink repair.Semantic proximity Read ↗

BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.Semantic proximity Read ↗

The DNA helicase FANCJ (BRIP1) functions in Double Strand Break repair processing, but not crossover formation during Prophase I of meiosis in male miceSemantic proximity Read ↗

Hereditary breast cancer and the BRCA1-associated FANCJ/BACH1/BRIP1.Semantic proximity Read ↗

A role for human homologous recombination factors in suppressing microhomology-mediated end joining.Semantic proximity Read ↗

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutationsSemantic proximity Read ↗

XRCC1 promotes replication restart, nascent fork degradation and mutagenic DNA repair in BRCA2-deficient cellsSemantic proximity Read ↗

The RecQ4 orthologue Hrq1 is critical for DNA interstrand cross-link repair and genome stability in fission yeast.Semantic proximity Read ↗

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks.Semantic proximity Read ↗

The DNA helicase FANCJ (BRIP1) functions in double strand break repair processing, but not crossover formation during prophase I of meiosis in male mice.Semantic proximity Read ↗

A cell cycle-dependent BRCA1-UHRF1 cascade regulates DNA double-strand break repair pathway choice.Semantic proximity Read ↗

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