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Article

Breast cancer risk and the DNA double-strand break end-joining capacity of nonhomologous end-joining genes are affected by BRCA1.

Cancer research - 15 Jul 2004

Bau Da-Tian, Fu Yi-Ping, Chen Shou-Tung, Cheng Ting-Chih, Yu Jyh-Cherng, Wu Pei-Ei, Shen Chen-Yang

Abstract excerpt

A tumorigenic role of the nonhomologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks (DSBs) has been suggested by the finding of a significant association between increased breast cancer risk and a cooperative effect of single nucleotide polymorphisms (SNPs) in NHEJ genes. However, the lack of an association between hereditary breast cancer and defective NHEJ genes prevents conclusions...

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Source

Identifiers

PMID: 15256476
DOI: 10.1158/0008-5472.CAN-04-0403

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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