Article
Unique tissue-specific level of DNA nucleotide excision repair in primary human mammary epithelial cultures.
Experimental cell research - 15 Nov 2003
Latimer Jean J, Nazir Tariq, Flowers Lisa C, Forlenza Michael J, Beaudry-Rodgers Kelly, Kelly Crystal M, Conte Julie A, Shestak Kenneth, Kanbour-Shakir Amal, Grant Stephen G
Abstract excerpt
DNA repair is essential for the maintenance of genomic integrity and stability. Nucleotide excision repair (NER) is a major pathway responsible for remediation of damage caused by UV light, bulky adducts, and cross-linking agents. We now show that NER capacity is differentially expressed in human tissues. We established primary cultures of peripheral blood lymphocytes (PBLs: N = 33) and foreskin fibroblasts (FF:...
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