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Article

The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

6 Jul 2017

Abstract excerpt

DNA double-strand breaks (DSBs) are deleterious DNA lesions that if left unrepaired or are misrepaired, potentially result in chromosomal aberrations, known drivers of carcinogenesis. Pathways that direct the repair of DSBs are traditionally believed to be guardians of the genome as they protect cells from genomic instability. The prominent DSB repair pathway in human cells is the non-homologous end joining...

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PMID: 28684677
DOI: 10.3390/cancers9070081

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