Article
Brca1 controls homology-directed DNA repair.
Molecular cell - 1 Oct 1999
Moynahan M E, Chiu J W, Koller B H, Jasin M
Abstract excerpt
Germline mutations in BRCA1 confer a high risk of breast and ovarian tumors. The role of BRCA1 in tumor suppression is not yet understood, but both transcription and repair functions have been ascribed. Evidence that BRCA1 is involved in DNA repair stems from its association with RAD51, a homolog of the yeast protein involved in the repair of DNA double-strand breaks (DSBs) by homologous recombination. We report...
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