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Article

BRCA1 facilitates microhomology-mediated end joining of DNA double strand breaks.

The Journal of biological chemistry - 9 Aug 2002

Zhong Qing, Chen Chi-Fen, Chen Phang-Lang, Lee Wen-Hwa

Abstract excerpt

BRCA1 is critical for the maintenance of genomic stability, in part through its interaction with the Rad50.Mre11.Nbs1 complex, which occupies a central role in DNA double strand break repair mediated by nonhomologous end joining (NHEJ) and homologous recombination. BRCA1 has been shown to be required for homology-directed recombination repair. However, the role of BRCA1 in NHEJ, a critical pathway for the repair...

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Source

Identifiers

PMID: 12039951
DOI: 10.1074/jbc.M200748200

Genes

BRCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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