Article
Regulation and disregulation of mammalian nucleotide excision repair: a pathway to nongermline breast carcinogenesis.
Photochemistry and photobiology - 1 Jan 2000
Latimer Jean J, Majekwana Vongai J, Pabón-Padín Yashira R, Pimpley Manasi R, Grant Stephen G
Abstract excerpt
Nucleotide excision repair (NER) is an important modulator of disease, especially in constitutive deficiencies such as the cancer predisposition syndrome Xeroderma pigmentosum. We have found profound variation in NER capacity among normal individuals, between cell-types and during carcinogenesis. NER is a repair system for many types of DNA damage, and therefore many types of genotoxic carcinogenic exposures,...
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