Article
A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining.
Oncogene - 21 Feb 2002
Baldeyron Céline, Jacquemin Emilie, Smith Julianne, Jacquemont Céline, De Oliveira Isabelle, Gad Sophie, Feunteun Jean, Stoppa-Lyonnet Dominique, Papadopoulo Dora
Abstract excerpt
Heterozygosity for mutations in the BRCA1 gene in humans confers high risk for developing breast cancer, but a biochemical basis for this phenotype has not yet been determined. Evidence has accumulated implicating BRCA1, in the maintenance of genomic integrity and the protection of cells against DNA double strand breaks (DSB). Here we present evidence that human cells heterozygous for BRCA1 mutations exhibit...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.