Article
Loss of function of a lupus-associated FcgammaRIIb polymorphism through exclusion from lipid rafts.
Nature medicine - 1 Oct 2005
Floto R Andres, Clatworthy Menna R, Heilbronn Karen R, Rosner Dalya R, MacAry Paul A, Rankin Angela, Lehner Paul J, Ouwehand Willem H, Allen Janet M, Watkins Nicholas A, Smith Kenneth G C
Abstract excerpt
Dysfunction of receptors for IgG (FcgammaRs) has been thought to be involved in the pathogenesis of systemic lupus erythematosus (SLE). We show that a recently described SLE-associated polymorphism of FcgammaRIIb (FcgammaRIIbT(232)), encoding a single transmembrane amino acid substitution, is functionally impaired. FcgammaRIIbT(232) is unable to inhibit activatory receptors because it is excluded from...
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