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Article

FcgammaRIIB deficiency with Fas mutation is sufficient for the development of systemic autoimmune disease.

European journal of immunology - 1 Apr 2003

Yajima Kaori, Nakamura Akira, Sugahara Akiko, Takai Toshiyuki

Abstract excerpt

MRL.Fas(lpr/lpr) mice, a model for systemic lupus erythematosus (SLE) and arthritis in humans, have a Fas mutation that results in spontaneous development of systemic autoimmune diseases and a short life span. Half of them die by 5-6 months of age due to massive progression of systemic autoimmune diseases, such as lupus nephritis. However, C57BL/6 (B6).Fas(lpr/lpr) strain does not develop such disorders within...

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PMID: 12672068
DOI: 10.1002/eji.200323794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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