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Article

Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Feb 2012

van der Heijden Joris, Breunis Willemijn B, Geissler Judy, de Boer Martin, van den Berg Timo K, Kuijpers Taco W

Abstract excerpt

The balance between activating and inhibitory signals from the different FcγRs for IgG ensures homeostasis of many inflammatory responses. FCGR2C is the product of an unequal crossover of the FCGR2A and FCGR2B genes encoding the activating FcγRIIa (CD32a) and inhibitory FcγRIIb (CD32b), respectively. A single nucleotide polymorphism (SNP) in exon 3 of FCGR2C results in either expression of the activating FcγRIIc...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22198951
DOI: 10.4049/jimmunol.1003945

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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