Article
FcgammaRIIB Ile232Thr transmembrane polymorphism associated with human systemic lupus erythematosus decreases affinity to lipid rafts and attenuates inhibitory effects on B cell receptor signaling.
Human molecular genetics - 1 Oct 2005
Kono Hajime, Kyogoku Chieko, Suzuki Takeshi, Tsuchiya Naoyuki, Honda Hiroaki, Yamamoto Kazuhiko, Tokunaga Katsushi, Honda Zen-Ichiro
Abstract excerpt
The B cell inhibitory receptor FcgammaRIIB plays crucial roles in the maintenance of self-tolerance. We have identified a polymorphism FCGR2B c.695T>C that results in the non-conservative replacement of 232Ile at the transmembrane helix to Thr and demonstrated the association of the polymorphism with susceptibility to systemic lupus erythematosus (SLE) in Asians. In this study, we examined the impact of FCGR2B...
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