Article
FcgammaR polymorphisms: Implications for function, disease susceptibility and immunotherapy.
Tissue antigens - 1 Mar 2003
van Sorge N M, van der Pol W-L, van de Winkel J G J
Abstract excerpt
Leukocyte Fcgamma receptors (FcgammaR) confer potent cellular effector functions to the specificity of IgG. FcgammaR-induced leukocyte functions, including antibody-dependent cellular cytotoxicity, phagocytosis, superoxide generation, degranulation, cytokine production and regulation of antibody production, are essential for host defense and immune regulation. The efficacy of IgG-induced FcgammaR function...
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