Article
A promoter haplotype of the immunoreceptor tyrosine-based inhibitory motif-bearing FcgammaRIIb alters receptor expression and associates with autoimmunity. I. Regulatory FCGR2B polymorphisms and their association with systemic lupus erythematosus.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2004
Su Kaihong, Wu Jianming, Edberg Jeffrey C, Li Xiaoli, Ferguson Polly, Cooper Glinda S, Langefeld Carl D, Kimberly Robert P
Abstract excerpt
FcgammaRIIb, the immunoreceptor tyrosine-based inhibitory motif-containing receptor for IgG (Mendelian Inheritance in Man no. 604590), plays an important role in maintaining the homeostasis of immune responses. We have identified 10 novel single-nucleotide polymorphisms in the promoter region of human FCGR2B gene and characterized two functionally distinct haplotypes in its proximal promoter. In luciferase...
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