Article

Role of lipid nanodomains for inhibitory FcγRIIb function

2023-05-12

Abstract excerpt

The inhibitory Fcγ receptor FcγRIIb is involved in immune regulation and is known to localize to specific regions of the plasma membrane called lipid rafts. Previous studies suggested a link between the altered lateral receptor localization within the plasma membrane and the functional impairment of the FcγRIIb-I232T variant that is associated with systemic lupus erythematosus. Here, we conducted microsecond all-a...

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Literature Corpus work: daab5ba3-b242-520b-a3a5-c86c70930059
DOI: 10.1101/2023.05.09.540011

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