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Article

A novel polymorphism in the Fcgamma receptor IIB (CD32B) transmembrane region alters receptor signaling.

Arthritis and rheumatism - 1 Nov 2003

Li Xiaoli, Wu Jianming, Carter Robert H, Edberg Jeffrey C, Su Kaihong, Cooper Glinda S, Kimberly Robert P

Abstract excerpt

OBJECTIVE: The low-affinity receptor Fcgamma receptor IIb (FcgammaRIIb), with an immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain, down-regulates humoral immune responses and modulates the risk of autoimmunity in animal models. The transmembrane domain of FcgammaRIIb may also contribute to receptor signaling. Therefore, we investigated the biologic significance of single-nucleotide...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 14613290
DOI: 10.1002/art.11313

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BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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