Article
Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.
Proceedings of the National Academy of Sciences of the United States of America - 24 Apr 2007
Clatworthy Menna R, Willcocks Lisa, Urban Britta, Langhorne Jean, Williams Tom N, Peshu Norbert, Watkins Nicholas A, Floto R Andres, Smith Kenneth G C
Abstract excerpt
Polygenic autoimmune diseases, such as systemic lupus erythematosus (SLE), are a significant cause of morbidity and mortality worldwide. In recent years, functionally important genetic polymorphisms conferring susceptibility to SLE have been identified, but the evolutionary pressures driving their retention in the gene pool remain elusive. A defunctioning, SLE-associated polymorphism of the inhibitory receptor...
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