Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.

doi:10.1053/j.gastro.2005.06.020

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Article

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.

Gastroenterology - 1 Sept 2005

Samowitz Wade S, Albertsen Hans, Herrick Jennifer, Levin Theodore R, Sweeney Carol, Murtaugh Maureen A, Wolff Roger K, Slattery Martha L

Abstract excerpt

BACKGROUND & AIMS: The concept of a CpG island methylator phenotype (CIMP), especially in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a large population-based sample of individuals with colon cancer and used univariate and multivariate analyses of CIMP with clinicopathologic variables and tumor mutations to determine the biologic relevance of this phenotype. METHODS: A...

Topics

Adaptor Proteins, Signal Transducing
Aged
Carrier Proteins
Colonic Neoplasms
DNA Methylation
Dinucleoside Phosphates
Female
Humans
Male
Microsatellite Repeats
Middle Aged

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

MutL Protein Homolog 1

Neoplasm Proteins

Neoplasm Staging

North Carolina

Nuclear Proteins

Patient Selection

Phenotype

Source

Open in PubMed

Identifiers

PMID: 16143123
DOI: 10.1053/j.gastro.2005.06.020

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-16143123-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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