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Article

Evaluation of a large, population-based sample supports a CpG island methylator phenotype in colon cancer.

Gastroenterology - 1 Sept 2005

Samowitz Wade S, Albertsen Hans, Herrick Jennifer, Levin Theodore R, Sweeney Carol, Murtaugh Maureen A, Wolff Roger K, Slattery Martha L

Abstract excerpt

BACKGROUND & AIMS: The concept of a CpG island methylator phenotype (CIMP), especially in microsatellite stable colon cancer, is not accepted universally. We therefore evaluated a large population-based sample of individuals with colon cancer and used univariate and multivariate analyses of CIMP with clinicopathologic variables and tumor mutations to determine the biologic relevance of this phenotype. METHODS: A...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 16143123
DOI: 10.1053/j.gastro.2005.06.020

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BRAF

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