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Article

Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.

The Journal of molecular diagnostics : JMD - 1 Jul 2007

Ogino Shuji, Kawasaki Takako, Kirkner Gregory J, Kraft Peter, Loda Massimo, Fuchs Charles S

Abstract excerpt

The CpG island methylator phenotype (CIMP or CIMP-high) with extensive promoter methylation is a distinct phenotype in colorectal cancer. However, a choice of markers for CIMP has been controversial. A recent extensive investigation has selected five methylation markers (CACNA1G, IGF2, NEUROG1, RUNX3, and SOCS1) as surrogate markers for epigenomic aberrations in tumor. The use of these markers as a CIMP-specific...

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Source

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Identifiers

PMID: 17591929
DOI: 10.2353/jmoldx.2007.060170
PMCID: PMC1899428

Genes

MLH1
IGF2
RUNX3
SOCS1
CRABP1
NEUROG1
BRAF
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.PMID 17591929Read ↗

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