Article
Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.
Development (Cambridge, England) - 1 Oct 2005
Hilton Matthew J, Tu Xiaolin, Cook Julie, Hu Hongliang, Long Fanxin
Abstract excerpt
Indian hedgehog (Ihh) controls multiple aspects of endochondral skeletal development, including proliferation and maturation of chondrocytes, osteoblast development and cartilage vascularization. Although it is known that Gli transcription factors are key effectors of hedgehog signaling, it has not been established which Gli protein mediates Ihh activity in skeletal development. Here, we show that removal of Gli3...
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