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Article

Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice.

PloS one - 1 Jan 2014

Kitaura Yoshiaki, Hojo Hironori, Komiyama Yuske, Takato Tsuyoshi, Chung Ung-il, Ohba Shinsuke

Abstract excerpt

Hedgehog (Hh) signaling plays important roles in various development processes. This signaling is necessary for osteoblast formation during endochondral ossification. In contrast to the established roles of Hh signaling in embryonic bone formation, evidence of its roles in adult bone homeostasis is not complete. Here we report the involvement of Gli1, a transcriptional activator induced by Hh signaling...

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Identifiers

PMID: 25313900
DOI: 10.1371/journal.pone.0109597
PMCID: PMC4196929

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