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Article

Impaired endochondral bone development and osteopenia in Gli2-deficient mice.

Experimental cell research - 10 Mar 2004

Miao Dengshun, Liu Hanlong, Plut Paul, Niu Meijuan, Huo Rujuan, Goltzman David, Henderson Janet E

Abstract excerpt

Mice homozygous for targeted disruption of the zinc finger domain of Gli2 (Gli2(zfd/zfd)) die at birth with developmental defects in several organ systems including the skeleton. The current studies were undertaken to define the role of Gli2 in endochondral bone development by characterizing the molecular defects in the limbs and vertebrae of Gli2(zfd/zfd) mice. The bones of mutant mice removed by cesarian...

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Source

Identifiers

PMID: 14980515
DOI: 10.1016/j.yexcr.2003.10.021

Genes

FGF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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