Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2015

Amano Katsuhiko, Densmore Michael J, Lanske Beate

Abstract excerpt

Indian hedgehog (Ihh) is widely recognized as an essential factor for proper skeletal development. Previous in vivo studies using mutant Ihh mouse models were limited by perinatal lethality or carried out after a growth plate formed. Thus the important role of Ihh in mesenchymal cell differentiation has not been investigated. In this study, we established Prx1-Cre;Ihh(fl/fl) mice to ablate Ihh specifically in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chondrocytes
Share to Extremities

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Growth Plate

Share to Hedgehog Proteins

Share to Mesoderm

Share to Osteoblasts

Share to Osteocalcin

Share to Osteoclasts

Source

Identifiers

PMID: 26094741
DOI: 10.1002/jbmr.2582

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.PMID 26094741Read ↗

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.Semantic proximity Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.Semantic proximity Read ↗

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Semantic proximity Read ↗

Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice.Semantic proximity Read ↗

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.Semantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

Some distal limb structures develop in mice lacking Sonic hedgehog signaling.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.Semantic proximity Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.