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Article

Role of hedgehog signaling in the pathogenesis and therapy of heterotopic ossification

19 Sept 2024

Abstract excerpt

Heterotopic ossification (HO) is a pathological process that generates ectopic bone in soft tissues. Hedgehog signaling (Hh signaling) is a signaling pathway that plays an important role in embryonic development and involves three ligands: sonic hedgehog (Shh), Indian hedgehog (Ihh) and desert hedgehog (Dhh). Hh signaling also has an important role in skeletal development. This paper discusses the effects of Hh...

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PMID: 39364140
DOI: 10.3389/fcell.2024.1454058

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