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Article

Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone.

Development (Cambridge, England) - 1 Jul 2012

Huycke Tyler R, Eames B Frank, Kimmel Charles B

Abstract excerpt

In the developing skeleton, dermal bone morphogenesis includes the balanced proliferation, recruitment and differentiation of osteoblast precursors, yet how bones acquire unique morphologies is unknown. We show that Hedgehog (Hh) signaling mediates bone shaping during early morphogenesis of the opercle (Op), a well characterized dermal bone of the zebrafish craniofacial skeleton. ihha is specifically expressed in...

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Identifiers

PMID: 22627283
DOI: 10.1242/dev.079806
PMCID: PMC3367445

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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