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Article

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.

Development (Cambridge, England) - 1 Mar 2005

Colnot Céline, de la Fuente Luis, Huang Steve, Hu Diane, Lu Chuanyong, St-Jacques Benoit, Helms Jill A

Abstract excerpt

A null mutation in the morphogen Indian hedgehog (IHH) results in an embryonic lethal phenotype characterized by the conspicuous absence of bony tissue in the extremities. We show that this ossification defect is not attributable to a permanent arrest in cartilage differentiation, since Ihh(-/-) chondrocytes undergo hypertrophy and terminal differentiation, express angiogenic markers such as Vegf, and are...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15689378
DOI: 10.1242/dev.01649

Genes

IHH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.PMID 15689378Read ↗

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Semantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.Semantic proximity Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.Semantic proximity Read ↗

Ihh and PTH1R signaling in limb mesenchyme is required for proper segmentation and subsequent formation and growth of digit bones.Semantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Hedgehog-dependent proliferation drives modular growth during morphogenesis of a dermal bone.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

Inactivation of Patched1 in the mouse limb has novel inhibitory effects on the chondrogenic program.Semantic proximity Read ↗

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