Article
Inactivation of Ihh in Sp7-Expressing Cells Inhibits Osteoblast Proliferation, Differentiation, and Bone Formation, Resulting in a Dwarfism Phenotype with Severe Skeletal Dysplasia in Mice.
Calcified tissue international - 1 Nov 2022
Wang YunFei, Dong Zhengquan, Yang Ruijia, Zong Sujing, Wei Xiaochun, Wang Chunfang, Guo Li, Sun Jian, Li Haoqian, Li Pengcui
Abstract excerpt
Indian hedgehog (Ihh) is an indispensable paracrine factor for proper tissue patterning, skeletogenesis, and cellular proliferation. Recent genetic studies have revealed critical roles of chondrocyte-derived Ihh in regulating chondrocyte proliferation, hypertrophy and cartilage ossification. However, the functions of Sp7-expressing cell-derived Ihh in osteoblast differentiation and bone formation remain unclear....
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