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Article

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.

Genes & development - 15 Aug 1999

St-Jacques B, Hammerschmidt M, McMahon A P

Abstract excerpt

The mechanisms that control cell proliferation and cell differentiation during morphogenesis of the endochondral skeleton of vertebrates are poorly understood. Indian hedgehog (Ihh) signaling from prehypertrophic chondrocytes has been implicated in the control of chondrocyte maturation by way of feedback control of a second secreted factor parathyroid hormone-related peptide (PTHrP) at the articular surfaces....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10465785
DOI: 10.1101/gad.13.16.2072
PMCID: PMC316949

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation.PMID 10465785Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.Semantic proximity Read ↗

Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Partial rescue of postnatal growth plate abnormalities in Ihh mutants by expression of a constitutively active PTH/PTHrP receptor.Semantic proximity Read ↗

Role of parathyroid hormone-related peptide and Indian hedgehog in skeletal development.Semantic proximity Read ↗

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

Indian Hedgehog, a critical modulator in osteoarthritis, could be a potential therapeutic target for attenuating cartilage degeneration diseaseSemantic proximity Read ↗

Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Semantic proximity Read ↗

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.Semantic proximity Read ↗

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