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Article

Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.

Development (Cambridge, England) - 1 Dec 2005

Koziel Lydia, Wuelling Manuela, Schneider Sabine, Vortkamp Andrea

Abstract excerpt

During endochondral ossification, the secreted growth factor Indian hedgehog (Ihh) regulates several differentiation steps. It interacts with a second secreted factor, parathyroid hormone-related protein (PTHrP), to regulate the onset of hypertrophic differentiation, and it regulates chondrocyte proliferation and ossification of the perichondrium independently of PTHrP. To investigate how the Ihh signal is...

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Source

Identifiers

PMID: 16284117
DOI: 10.1242/dev.02097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.PMID 16284117Read ↗

Regulation of rate of cartilage differentiation by Indian hedgehog and PTH-related protein.Semantic proximity Read ↗

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Ihh controls cartilage development by antagonizing Gli3, but requires additional effectors to regulate osteoblast and vascular development.Semantic proximity Read ↗

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy.Semantic proximity Read ↗

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Indian hedgehog stimulates periarticular chondrocyte differentiation to regulate growth plate length independently of PTHrP.Semantic proximity Read ↗

Long bone development requires a threshold of Hox function.Semantic proximity Read ↗

The Transcription Factor Hand1 Is Involved In Runx2-Ihh-Regulated Endochondral Ossification.Semantic proximity Read ↗

Conditional Deletion of Indian Hedgehog in Limb Mesenchyme Results in Complete Loss of Growth Plate Formation but Allows Mature Osteoblast Differentiation.Semantic proximity Read ↗

BMP and Ihh/PTHrP signaling interact to coordinate chondrocyte proliferation and differentiationSemantic proximity Read ↗

Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development.Semantic proximity Read ↗

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