Article
Gli3 acts as a repressor downstream of Ihh in regulating two distinct steps of chondrocyte differentiation.
Development (Cambridge, England) - 1 Dec 2005
Koziel Lydia, Wuelling Manuela, Schneider Sabine, Vortkamp Andrea
Abstract excerpt
During endochondral ossification, the secreted growth factor Indian hedgehog (Ihh) regulates several differentiation steps. It interacts with a second secreted factor, parathyroid hormone-related protein (PTHrP), to regulate the onset of hypertrophic differentiation, and it regulates chondrocyte proliferation and ossification of the perichondrium independently of PTHrP. To investigate how the Ihh signal is...
Topics
- Animals
- Cell Differentiation
- Cell Enlargement
- Cell Proliferation
- Chondrocytes
- Gene Expression Regulation
- Hedgehog Proteins
- Intracellular Signaling Peptides and Proteins
- Kruppel-Like Transcription Factors
- Membrane Proteins
- Mice
- Mice, Transgenic
- Mutation
- Nerve Tissue Proteins