Article
IGF-I Signaling in Osterix-Expressing Cells Regulates Secondary Ossification Center Formation, Growth Plate Maturation, and Metaphyseal Formation During Postnatal Bone Development.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Dec 2015
Wang Yongmei, Menendez Alicia, Fong Chak, ElAlieh Hashem Z, Kubota Takuo, Long Roger, Bikle Daniel D
Abstract excerpt
To investigate the role of IGF-I signaling in osterix (OSX)-expressing cells in the skeleton, we generated IGF-I receptor (IGF-IR) knockout mice ((OSX)IGF-IRKO) (floxed-IGF-IR mice × OSX promoter-driven GFP-labeled cre-recombinase [(OSX)GFPcre]), and monitored postnatal bone development. At day 2 after birth (P2), (OSX)GFP-cre was highly expressed in the osteoblasts in the bone surface of the metaphysis and in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.