Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.

doi:10.1016/j.cub.2005.07.061

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Article

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.

Current biology : CB - 6 Sept 2005

Bhalerao Sheetal, Berdnik Daniela, Török Tibor, Knoblich Juergen A

Abstract excerpt

During asymmetric cell division, protein determinants are segregated into one of the two daughter cells. The Numb protein acts as a segregating determinant during both mouse and Drosophila development. In flies, Numb localizes asymmetrically and is required for cell-fate specification in the central and peripheral nervous systems, as well as during muscle and heart development. Whether its asymmetric segregation...

Topics

Animals
Cell Differentiation
Cell Division
Drosophila
Drosophila Proteins
Immunohistochemistry
Juvenile Hormones
Muscles
Mutation
Peripheral Nervous System
Protein Transport
Transgenes

Source

Open in PubMed

Identifiers

PMID: 16139215
DOI: 10.1016/j.cub.2005.07.061

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