Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS.

Development (Cambridge, England) - 1 Jun 1999

Wai P, Truong B, Bhat K M

Abstract excerpt

Cell intrinsic and cell extrinsic factors mediate asymmetric cell divisions during neurogenesis in the Drosophila embryo. In the NB4-2->GMC-1->RP2/sib lineage, one of the well-studied neuronal lineages in the ventral nerve cord, the Notch (N) signaling interacts with the asymmetrically localized Numb (Nb) to specify sibling neuronal fates to daughter cells of GMC-1. In this current study, we have investigated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclin A
Share to Embryonic Induction
Share to Ganglia, Invertebrate

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Juvenile Hormones

Share to Metaphase

Share to Nocodazole

Share to Phosphoprotein Phosphatases

Share to Receptors, Notch

Source

Identifiers

PMID: 10331986
DOI: 10.1242/dev.126.12.2759

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cell division genes promote asymmetric interaction between Numb and Notch in the Drosophila CNS.PMID 10331986Read ↗

Neural cell fate in rca1 and cycA mutants: the roles of intrinsic and extrinsic factors in asymmetric division in the Drosophila central nervous system.Semantic proximity Read ↗

Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.Semantic proximity Read ↗

cdc2 links the Drosophila cell cycle and asymmetric division machineries.Semantic proximity Read ↗

Mother-daughter precursor cell fate transformation after Cdc2 down-regulation in the Drosophila bristle lineage.Semantic proximity Read ↗

Differential effects of Drosophila mastermind on asymmetric cell fate specification and neuroblast formation.Semantic proximity Read ↗

Localization-dependent and -independent roles of numb contribute to cell-fate specification in Drosophila.Semantic proximity Read ↗

Slit signaling promotes the terminal asymmetric division of neural precursor cells in the Drosophila CNS.Semantic proximity Read ↗

The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb.Semantic proximity Read ↗

Asymmetric localization of a mammalian numb homolog during mouse cortical neurogenesis.Semantic proximity Read ↗

Evidence of asymmetric cell division and centrosome inheritance in human neuroblastoma cellsSemantic proximity Read ↗

Numb antagonizes Notch signaling to specify sibling neuron cell fates.Semantic proximity Read ↗

Jumeaux, a novel Drosophila winged-helix family protein, is required for generating asymmetric sibling neuronal cell fates.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.