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Article

Notch regulates numb: integration of conditional and autonomous cell fate specification.

Development (Cambridge, England) - 1 Jan 2011

Rebeiz Mark, Miller Steven W, Posakony James W

Abstract excerpt

The Notch cell-cell signaling pathway is used extensively in cell fate specification during metazoan development. In many cell lineages, the conditional role of Notch signaling is integrated with the autonomous action of the Numb protein, a Notch pathway antagonist. During Drosophila sensory bristle development, precursor cells segregate Numb asymmetrically to one of their progeny cells, rendering it unresponsive...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 21148185
DOI: 10.1242/dev.050161
PMCID: PMC3005598

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Notch regulates numb: integration of conditional and autonomous cell fate specification.PMID 21148185Read ↗

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