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Article

The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis.

Cell - 6 Apr 2007

Zhou Yan, Atkins Joshua B, Rompani Santiago B, Bancescu Daria L, Petersen Petur H, Tang Haiyan, Zou Kaiyong, Stewart Sinead B, Zhong Weimin

Abstract excerpt

Mammalian neural progenitor cells divide asymmetrically to self-renew and produce a neuron by segregating cytosolic Numb proteins primarily to one daughter cell. Numb signaling specifies progenitor over neuronal fates but, paradoxically, also promotes neuronal differentiation. Here we report that ACBD3 is a Numb partner in cell-fate specification. ACBD3 and Numb proteins interact through an essential Numb domain,...

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Source

Identifiers

PMID: 17418793
DOI: 10.1016/j.cell.2007.02.037

Genes

ACBD3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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