Article
Binary sibling neuronal cell fate decisions in the Drosophila embryonic central nervous system are nonstochastic and require inscuteable-mediated asymmetry of ganglion mother cells.
Genes & development - 15 Jun 1998
Buescher M, Yeo S L, Udolph G, Zavortink M, Yang X, Tear G, Chia W
Abstract excerpt
Asymmetric cell division is a widespread mechanism in developing tissues that leads to the generation of cell diversity. In the embryonic central nervous system of Drosophila melanogaster, secondary precursor cells-ganglion mother cells (GMCs)-divide and produce postmitotic neurons that take on different cell fates. In this study, we show that binary fate decision of two pairs of sibling neurons is accomplished...
Topics
- Animals
- Carrier Proteins
- Cell Differentiation
- Cell Division
- Cell Lineage
- Cell Nucleus
- Cell Size
- Central Nervous System
- Cytoskeletal Proteins
- Drosophila Proteins